HCID 12043292, compound → HCID 131723475, compound

Participants

Reaction Steps

The compound of Example 4 and 4-(cyclohexyl)-1-piperazinepropanamine were reacted according to the General Procedure of Example 13 to yield 1,4-dihydro-2,6-dimethyl-4-[5-[[3-(4-cyclohexyl-1-piperazinyl) propyl]amino]-5-oxopentyl]-3,5-pyridine dicarboxylic acid, dimethyl ester. 1H NMR (DMSO-d6) δ 8.71 (s, 1 H), 8 7.70 (br. t, 1 H), 3.75 (t, 1 H, J=5.4 Hz), 3.59 (s, 6 H), 3.15 (m, 1 H), 2.99 (m, 2 H), 2.45 (m,4 H),2.15 (s,6 H), 1.94 (t, 2 H, J=7.3 Hz), 1.7 (m, 4 H), 1.4-1.2 (m, 9 H), 1.2-1.0 (m, 11 H); 13C NMR (DMSO-d6) δ 171.8, 167.6, 146.3, 100.5, 62.5, 55.6, 53.4, 50.5, 48.4, 44.8, 36.9, 36.5, 35.6, 34.0, 32.0, 28.4, 26.4, 25.9, 25.6, 18.1. Analysis calculated for C29H48N4O5. 2.0 H2O: C, 61.24; H, 9.22; N, 9.85. Found: C, 61.44; H, 9.30; N, 10.53.

Provenance & Evidence