Succinimide → HCID 18430869, compound

Participants

Reaction Steps

To a mixture of 3-(4-benzylpiperazin-1-yl)propan-1-ol (48.5 g/0.21 mol), triphenylphosphine (81.6 g/0.31 mol), succimide (30.7 g/0.31 mol) in tetrahydrofuran (1000 ml) was added dropwise diethylazodicarboxylate (49.0 ml/0.31 mol) and the mixture was stand overnight. The solvent was removed in vacuo and the residue was purified by column chromatography (Si/230-400 mesh/dichloromethane:methanol=15:1) to give a colorless oil (55.1 g/83%).

Provenance & Evidence