Sodium hydride → HCID 18430906, compound

Participants

Reaction Conditions

Reaction Steps

Sodium hydride(60% in oil, 0.5 g/12.5 mmol) was added to a solution of 2-chloroethyl 3-(4-benzyl-1-piperazinyl)propylcarbamate in dimethylformamide(20 ml) and stirred for 1 day at 80° C. The solvent was removed in vacuo and the residue was diluted with dichloromethane (50 ml) and water (50 ml). The aqueous layer was extracted with dichloromethane (50 ml). The combined extracts were washed with brine (50 ml), dried over magnesium sulfate, filtered and concentrated in vacuo. The residue was purified by column chromatography (NH2 gel/dichloromethane) to give a colorless oil (1.40 g/54%).

Provenance & Evidence