HuagongsheHuagongshe Chemistry Print Report · For research reference only
Brofoxine → 6-(3,5Dichloro-phenyl)4,4-dimethyl-1,4-dihydrobenzo[d][1,3]-oxazin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Brofoxine | HCID 30630 | — |
| Reactant | 3,5-Dichlorophenylboronic acid | HCID 2734331 | — |
| Product | 6-(3,5Dichloro-phenyl)4,4-dimethyl-1,4-dihydrobenzo[d][1,3]-oxazin-2-one | HCID 9927148 | — |
Reaction Steps
Prepared from 6-bromo-4,4-dimethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one and 3,5-dichlorophenyl boronic acid according to Procedure A. A white solid: mp 245-246° C.; 1H-NMR (DMSO-d6) δ10.4 (s, 1H), 7.77 (m, 2H), 7.67-7.64 (m, 2H), 7.56 (bs, 1H), 6.96 (d, 1H, J=7.98 Hz), 1.7 (s, 6H); MS (EI) m/z 321 ([M+H]+, 40%); Anal. Calc. For C16H13Cl2NO2: C, 59.32, H, 4.11, N, 4.32. Found: C, 59.13, H, 4.29, N, 4.17.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06444668B1 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-fe3409543f274b6c80f7a3f04584b94d |
| Source note | uspto-grants-2002_09 |