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HRID1278669

反应详情

EQUATION

反应方程式

HRID 1278669 的结构方程式

REACTANTS

反应物

2
结构：CC1(C)OC(=O)Nc2ccc(Br)cc21
HCID30630

Brofoxine

C10H10BrNO2

结构：Fc1ccc(Br)cc1Cl
HCID3543065

4-Bromo-2-chloro-1-fluorobenzene

C6H3BrClF

PRODUCTS

生成物

1
结构：CC1(C)OC(=O)Nc2ccc(-c3ccc(F)c(Cl)c3)cc21
HCID9904610

6-(3-chloro-4-fluorophenyl)-4,4-dimethyl-1H-3,1-benzoxazin-2-one

C16H13ClFNO2

PROCEDURE

实验过程

Prepared from 6-bromo-4,4-dimethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one and 1-bromo-3-chloro-4-fluorobenzene according to Procedure A. White solid: mp 211-212° C.; 1H-NMR (DMSO-d6) δ10.4 (s, 1H), 7.92 (dd, 1H, J=7.13, 2.19 Hz), 7.71-7.66 (m, 1H), 7.60-7.57 (m, 2H), 7.49 (t, 1H, J=8.95 Hz), 6.96 (d, 1J=8.01 Hz), 1.67 (s, 6H); MS (EI) m/z 305 ([M +H]+, 20%); Anal. Calc. For C16H13ClFNO2: C, 62.86, H, 4.29, N, 4.58. Found: C, 62.52, H, 4.45, N, 4.42.