反应详情

Prepared according to procedure B from 4-bromo-2-fluorophenylacetonitrile (T. Alessi A.H.P. U.S. Pat. No.: 4,895,862) and (1,4-dihydro-4,4-dimethyl-2-oxo-2H-3,1-benzoxazin-6-yl)boronic acid. A grey solid; mp 253-256° C. 1HNMR(DMSO-d6)□ 10.35 (s, 1H) 7.67-7.49(m,5H), 6.97(d,1H; J=8.6 Hz) 4.09 (s,2H) 1.67(s, 6H); MS [M−H]− m/z 309. Anal. Calc. For C18H15N2FO2. 0.15H20: C,69.07, H, 4.93, N, 8.95. Found C,69.27, H 5.05, N, 8.50

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