Trifluoroacetic acid → HCID 10122037, compound

Participants

Reaction Steps

To a solution of 2-(2-butynyl)-2-[(4-{4-[((2R)-2-hydroxy-2-[4-hydroxy-3-[(methylsulfonyl)amino)-phenyl)ethyl)amino]-1-piperidinyl}phenyl)sulfonyl]-4-hexynoicacid tert-butyl ester 0.21 g (0.3 mmol) in dichloromethane (3 ml) was added trifluoroacetic acid (0.23 ml, 3 mmol), and the mixture was stirred at room temperature for 2 days. It was then evaporated and treated with 10% sodium bicarbonate solution until pH 6. The resulting suspension was filtered and the precipitate washed with water, and dried in vacuo to give 85 mg of a beige solid; m.p. 175-177° C.; MS (ES) m/z 630.6 (M−H−); HRMS (EI) Calcd. for C30H36N3O8S2 (M−H−): 630.1949, Found: 630.1943.

Provenance & Evidence