HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrazole → HCID 54149163, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrazole | HCID 1048 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 17-Chloro-16-formylandrosta-5,16-dien-3beta-yl acetate | HCID 10474701 | — |
| Reactant | HCID 54223629 | HCID 54223629 | — |
| Product | HCID 54149163 | HCID 54149163 | 62.8% |
Reaction Steps
Reaction of 3β-acetoxy-17-chloro-16-formylandrosta-5,16-diene (Compound 3) (0.5 g, 1.329 mmol), pyrazole (136 mg, 1.994 mmol) and K2CO3 (551 mg, 3.99 mmol) as described for Synthesis Example 7 after FCC (silica gel, pet. ether/EtOAc, (4:1)) gave a mixture (341 mg, approx. 3:1) of 3β-acetoxy-17-(1H-pyrazol-1-yl)-16-formylandrosta-5,16-diene and 3β-acetoxy-17-(1H-pyrazol-1-yl)androsta-5-ene. This mixture resisted separation by chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06444683B2 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-68acc9cb75a34081acb43231c706aa7d |
| Source note | uspto-grants-2002_09 |