反应详情

温度

65 °C

A solution of 11-phenoxyundecanoyl chloride (31.1 g, 104.8 mmoles) in acetone (30 ml) was dropped into a solution of sodium azide (9.53 g, 146.6 mmoles) in water (30 ml), cooled in an ice bath, keeping the solution temperature between 10 and 15° C. After one hour, the solution was transferred in a separatory funnel and the lower phase (the aqueous one) was eliminated. The higher phase was transferred into a flask containing 100 ml of toluene, previously warmed at 65° C. After 1.5 hours, the solution was evaporated to dryness, giving 13.37 g of crude product, which could be used as such in the subsequent reaction.

1. temperaturecooled in an ice bath
2. customthe solution temperature between 10 and 15° C
3. customthe solution was transferred in a separatory funnel
4. customThe higher phase was transferred into a flask
5. waitAfter 1.5 hours
6. customthe solution was evaporated to dryness