HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-(5-fluoro-6-methyl-2-pyridinyl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 5-(5-fluoro-6-methyl-2-pyridinyl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione | HCID 24759551 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 5-(5-fluoro-6-methyl-2-pyridinyl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione dihydrochloride | HCID 86615959 | 5% |
Reaction Steps
5-(5-fluoro-6-methyl-2-pyridinyl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione (8 mg) was dissolved in dioxane and then a solution of 4N HCl in dioxane (2 eq) was added to give the title compound as pale yellow solid (8 mg, 5% yield)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07727988B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-dc5d270405fc40b98bb85cd651c8bce8 |
| Source note | uspto-grants-2010_06 |