反应详情

A mixture of 4,5-diphenyl-2-oxo-4-oxazolin-3-ylacetic acid (2.1 g, 7.1 mmol) [J. Org. Chem., 38, 3034 (1973)], thionyl chloride (5 ml) and methylene chloride (20 ml) is refluxed for 2.5 hours. After cooling to room temperature the solvent is removed in vacuo and resulting oil crystallizes on standing. The product is triturated with ether-hexane to give the title compound; 2.0 g mp 104°-112°.

1. temperatureis refluxed for 2.5 hours
2. customis removed in vacuo
3. customresulting oil
4. customcrystallizes on standing
5. customThe product is triturated with ether-hexane