反应详情

Acetic acid 6-(diisopropoxy-phosphoryl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester (467 mg, 1.22 mmol) in dry methanol (10 mL) and methanolic sodium methoxide (0.1M, 1 mL) was stirred at RT for 0.5 h. Dowex acidic resin was added until neutral pH was attained, the reaction mixture filtered and concentrated to give (6-Hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-phosphonic acid diisopropyl ester as a colorless syrup (409 mg, 99%).

1. additionDowex acidic resin was added until neutral pH
2. filtrationthe reaction mixture filtered
3. concentrationconcentrated