Potassium Carbonate → HCID 22969100, compound

Participants

Reaction Steps

To a solution of Benzoic acid 5-(diisopropoxy-phosphoryl)-3-methoxy-tetrahydro-furan-2-ylmethyl ester (266 mg, 0.66 mmol) in methanol (3 mL) was added potassium carbonate (45 mg, 0.33 mmol) and stirred for 5 hours at RT. Dowex acidic resin was added until neutral pH was attained, the reaction mixture filtered and concentrated to give (5-Hydroxymethyl-4-methoxy-tetrahydro-furan-2-yl)-phosphonic acid diisopropyl ester (168 mg, 85%).

Provenance & Evidence