反应详情

A solution of 1.6 g (8.85 mmol) of 3-bromo-2-ketobutyric acid and 7 g (4 equivalents) of O-t-butyl-N,N'-diisopropylpseudourea in 14 ml methylene chloride is stirred overnight at room temperature. After filtration, the solution is washed with NaHCO3 and brine, dried and evaporated to an oil which is chromatographed on silica gel with benzene as eluant to give 1 g (45%) of t-butyl 3-bromo-2-ketobutyrate.

1. filtrationAfter filtration
2. washthe solution is washed with NaHCO3 and brine
3. customdried
4. customevaporated to an oil which
5. customis chromatographed on silica gel with benzene as eluant