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HRID1278901

反应详情

EQUATION

反应方程式

HRID 1278901 的结构方程式

REACTANTS

反应物

2
结构：O=CO
HCID284

Formic acid

CH2O2

结构：CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O
HCID84029

Clarithromycin

C38H69NO13

PRODUCTS

生成物

1
结构：CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O.O=C[O-]
HCID86758498

未命名化合物

收率 94%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)=O
溶剂HCID180

Acetone

C3H6O

CONDITIONS

反应条件

温度
0 °C

PROCEDURE

实验过程

7.48 g of clarithromycin (purity: 95.4%) was suspended in 70 ml of acetone, and 0.49 ml of formic acid was added thereto and refluxed for 30 minutes. The suspension was cooled to 0° C. and stirred for 2 hours. Then, the resulting crystals were filtered, washed with cold acetone and dried to give 7.42 g of clarithromycin formate (purity: 97.9%, yield: 94%).

WORKUP

后处理

  1. temperaturerefluxed for 30 minutes
  2. filtrationThen, the resulting crystals were filtered
  3. washwashed with cold acetone
  4. customdried