HuagongsheHuagongshe Chemistry Print Report · For research reference only
5,12-Naphthacenedione → Doxorubicin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5,12-Naphthacenedione | HCID 14160 | — |
| Reactant | Doxorubicin Hydrochloride | HCID 443939 | — |
| Product | Doxorubicin | HCID 31703 | — |
Reaction Steps
Doxorubicin hydrochloride, 5,12-Naphthacenedione, (8s-cis)-10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11 -trihydroxy-8-(hydroxyacetyl)-1-methoxy-hydrochloride (hydroxydaunorubicin hydrochloride, Adriamycin) is used in a wide antineoplastic spectrum. It binds to DNA and inhibits nucleic acid synthesis, inhibits mitosis and promotes chromosomal aberrations.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06444872B1 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-3cbd80ce8cd84674aa1c2c0b9814bd84 |
| Source note | uspto-grants-2002_09 |