6-Bromo-1-chloro-isoquinoline → 7-Bromo-1-Chloroisoquinoline

HRID 1279018Notes

Reaction equation

HRID 1279018 reaction equation
Cl.[Br:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][N+:9]([O-])=[CH:10]2)=[CH:5][CH:4]=1.BrC1C=C2C(=CC=1)C([Cl:25])=NC=C2>>[Br:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][N:9]=[C:10]2[Cl:25])=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 222502446-Bromo-1-chloro-isoquinolineHCID 226659267-Bromoisoquinoline N-oxide hydrochloride

Product 1

HCID 65020247-Bromo-1-Chloroisoquinoline

Procedure

Compound 37b was prepared from 37a using the procedure described for 1b. 1H-NMR 200 MHz (CDCl3)δ: 7.57-7.88 (3H, m), 8.32 (1H, d, J=6 Hz), 8.51-8.54 (1H, m)

Sources & evidence

ORD record
ord-7a7972c47feb4852a4e6e22516446684
Source dataset
uspto-grants-2002_09
Patent number
US06444672B1

Reaction notes

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