1-Amino-6-bromoisoquinoline → 7-Bromoisoquinolin-1-amine

HRID 1279019Notes

Reaction equation

HRID 1279019 reaction equation
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[C:9]2OC2C=CC=CC=2)=[CH:4][CH:3]=1.[NH2:19]C1C2C(=CC(Br)=CC=2)C=CN=1>>[NH2:19][C:9]1[C:10]2[C:5](=[CH:4][CH:3]=[C:2]([Br:1])[CH:11]=2)[CH:6]=[CH:7][N:8]=1

Participants

3

Reactant 2

HCID 226076161-Amino-6-bromoisoquinolineHCID 226658407-Bromo-1-phenoxyisoquinoline

Product 1

HCID 226657347-Bromoisoquinolin-1-amine

Procedure

Compound 37d was prepared from 37c using the procedure described for 1d. 1H-NMR 200 MHz (CDCl3) δ: 5.1 (2H, br. s), 7.03 (1H, dd, J=6 Hz and J=1 Hz), 7.59 (1H, d, J=9 Hz), 7.70 (1H, dd, J=9 Hz and J=2 Hz), 7.95-8.00 (2H, m).

Sources & evidence

ORD record
ord-63c7b63071b1425db1b72c5b9adda0a9
Source dataset
uspto-grants-2002_09
Patent number
US06444672B1

Reaction notes

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