7-Bromoisoquinolin-1-amine → N-(7-bromo-1-isoquinolinyl)benzamide

HRID 1279020Notes

Reaction equation

HRID 1279020 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([Br:12])[CH:10]=2)[CH:5]=[CH:4][N:3]=1.BrC1C=C2C(=CC=1)C(N[C:25](=[O:32])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)=NC=C2>>[Br:12][C:9]1[CH:10]=[C:11]2[C:6]([CH:5]=[CH:4][N:3]=[C:2]2[NH:1][C:25](=[O:32])[C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 226657347-Bromoisoquinolin-1-amineHCID 22665824N-(6-bromo-1-isoquinolinyl)benzamide

Product 1

HCID 22665843N-(7-bromo-1-isoquinolinyl)benzamide

Procedure

Compound 37e was prepared from 37d using the procedure described for 1e. 1H-NMR 200 MHz (CDCl3) δ: 6.98 (1H, d, J=6 Hz), 7.37-7.57 (6H, m), 8.41-8.48 (2H, m), 9.14 (1H, d, J=2 Hz).

Sources & evidence

ORD record
ord-372734c408d34960ad1f46453a9e3506
Source dataset
uspto-grants-2002_09
Patent number
US06444672B1

Reaction notes

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