HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methoxybenzenesulfonyl chloride → HCID 69780457, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methoxybenzenesulfonyl chloride | HCID 7401 | — |
| Reactant | 4-tert-Butyl hydrogen L-aspartate | HCID 7010570 | — |
| Reactant | 1,1-Dimethylethyl 1-[(1-amino-6-isoquinolinyl)methyl]-2-oxo-2-(1-piperidinyl)ethyl-carbamate | HCID 22665607 | — |
| Reactant | N-[1-[(1-Amino-6-isoquinolinyl)methyl]-2-oxo-2-(1-piperidinyl)ethyl]-2-[[(3,4-dihydro-2,2,5,7,8-pentamethyl-2H-1-benzopyran-6-yl)sulfonyl]amino]acetamide hydrochloride | HCID 22665631 | — |
| Reactant | HCID 69781634 | HCID 69781634 | — |
| Product | HCID 69780457 | HCID 69780457 | — |
Reaction Steps
The procedure described for 5c was used. Deprotection of 100 mg of 5a and coupling with 99 mg of (2S)-[[(4-methoxyphenyl)sulfonyl]amino]butanedioic acid 4-(1,1-dimethylethyl)ester (prepared from Asp(OtBu)-OH and 4-methoxyphenylsulfonylchloride using the procedure described for 5b) yielded the title compound (85 mg) as a mixture of diastereomers (1:1). 1H-NMR 400 MHz (CD3OD) δ: 1.25-1.67 (6H, m), 1.32 and 1.35 (9H, 2× s), 2.18-2.48 (2H, m), 3.96-3.55 (6H, m), 3.83 and 3.86 (3H, 2× s), 4.04-4.14 (1H, m), 5.05-5.17 (1H, m), 6.99-7.05 (2H, m), 7.19-7.23 (1H, m), 7.51-7.79 (5H, m), 8.30-8.36 (1H, m).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06444672B1 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-22d1e88ca4dc4c64b8aaa919016b196d |
| Source note | uspto-grants-2002_09 |