4-(2-Methoxyethoxy)benzene-1-sulfonyl chloride → N-[1-(4-Amino-thieno[3,2-c]pyridin-2-ylmethyl)-2-(4-methyl-piperidin-1-yl)-2-oxo-ethyl]-4-(2-methoxy-ethoxy)-benzenesulfonamide

Participants

Role	Name	HCID	Charge
Reactant	4-(2-Methoxyethoxy)benzene-1-sulfonyl chloride	HCID 22507216	—
Reactant	N-[1-(4-Amino-thieno[3,2-c]pyridin-2-ylmethyl)-2-(4-methyl-piperidin-1-yl)-2-oxo-ethyl]-4-(tetrahydropyran-4-yloxy)-benzenesulfonamide	HCID 22665795	—
Product	N-[1-(4-Amino-thieno[3,2-c]pyridin-2-ylmethyl)-2-(4-methyl-piperidin-1-yl)-2-oxo-ethyl]-4-(2-methoxy-ethoxy)-benzenesulfonamide	HCID 22665719	—

Reaction Steps

This compound was prepared from 0.6 mmol 4-(2-methoxy-ethoxy)-benzenesulfonyl chloride and 210 mg (0.5 mmol) of 30a using the procedure described for 58c. Yield: 30 mg (white crystals), m.p. 210° C. (decomp.), EI-MS: 532 (M+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06444672B1
Source dataset	uspto-grants-2002_09
ORD ID	ord-1946472b27124c1a9670e79f39d1791f
Source note	uspto-grants-2002_09