HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → N-[6-(aminomethyl)-1-isoquinolinyl]benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | N-[6-(azidomethyl)-1-isoquinolinyl]benzamide | HCID 22665816 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-[6-(aminomethyl)-1-isoquinolinyl]benzamide | HCID 22665809 | — |
Reaction Steps
A solution of 6.4 g of N-[6-(azidomethyl)-1-isoquinolinyl]benzamide in 300 mL of ethanol and 60 mL of N,N-dimethylformamide containing 3.8 g of 5% palladium/calcium carbonate was hydrogenated for 20 hours. Filtration and concentration i. vac. yielded the title compound as an oil. MS (m/e)=277.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06444672B1 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-24f91707a6f74d16b0fe6eb7c25f5aa9 |
| Source note | uspto-grants-2002_09 |