HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1279071Generated: October 26, 2026
Phosphorus oxychloride → 1-Chloro-7-methoxyisoquinoline
https://huagongshe.com/reaction/1279071
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 7-Methoxy-isoquinoline-N-oxide hydrochloride | HCID 22665683 | — |
| Product | 1-Chloro-7-methoxyisoquinoline | HCID 22250181 | — |
Reaction Steps
7-Methoxy-isoquinoline-N-oxide hydrochloride (38.2 g) was added in portions to phosphoryl chloride (275 mL) and the mixture heated at 90° C. for 6 h. Excess of phosphoryl chloride was removed in vacuo. The remaining white solid was washed with water, filtered and dried in vacuo. Yield: 28.3 g (81%) m.p. 77-78° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06444672B1 |
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| Source dataset | uspto-grants-2002_09 |
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| ORD ID | ord-11407820e6a3420c8c1c92f4fec60072 |
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| Source note | uspto-grants-2002_09 |
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