反应详情

Liquid ammonia (210 mL) was added to a mixture of 4.2 g of 1-amino-isoquinoline-7-carbonitrile and 4.0 g of Raney-Ni in 210 mL of methanol in a steel vessel. hydrogen was pressed upon until an initial pressure of 100 atm. was obtained. This mixture was reacted for 16 hours at ambient temperature, the catalyst subsequently removed by filtration and the solvent pumped off. The residue was purified by silica chromatography (methanol/ammonia saturated methanol=85:15, 8:2) yielding 1.1 g (25%) of the title compound as a light yellow solid. M.p. 114-117° C.

1. customwas obtained
2. customThis mixture was reacted for 16 hours at ambient temperature
3. customthe catalyst subsequently removed by filtration
4. customThe residue was purified by silica chromatography (methanol/ammonia saturated methanol=85:15, 8:2)