HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → 4-Aminofuro[3,2-c]pyridine-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 1-Aminoisoquinoline-7-carbonitrile | HCID 22665848 | — |
| Reactant | 2-Iodofuro[3,2-c]pyridin-4-amine | HCID 22665905 | — |
| Catalyst | Zinc cyanide (Zn(CN)2) | HCID 11186 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 4-Aminofuro[3,2-c]pyridine-2-carbonitrile | HCID 22665808 | — |
Reaction Steps
This compound was prepared from 2-iodo-furo[3,2-c]pyridin-4-ylamine (5.2 g), zinc cyanide (3.6 g), triphenylphosphine (2.1 g) and palladium acetate (1.8 g) in 75 mL of N-methyl-pyrrolidone using the procedure described for 1-amino-isoquinoline-7-carbonitrile . Yield: 2.0 g (64%); yellow solid; m.p. 280° C. (decomp.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06444672B1 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-cfcfd564e57c4debb0049a39b61df306 |
| Source note | uspto-grants-2002_09 |