HuagongsheHuagongshe Chemistry Print Report · For research reference only
Proline benzyl ester hydrochloride → 1-[(R)-Methoxycarbonylamino-cyclohexyl-acetyl]-pyrrolidine-2-(S)-carboxylic acid benzyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Proline benzyl ester hydrochloride | HCID 2733413 | — |
| Reactant | (R)-methoxycarbonylamino-cyclohexyl-acetic acid | HCID 53880278 | — |
| Product | 1-[(R)-Methoxycarbonylamino-cyclohexyl-acetyl]-pyrrolidine-2-(S)-carboxylic acid benzyl ester | HCID 53855171 | 50.5% |
Reaction Steps
Reaction of 1.24 g of (R)-methoxycarbonylamino-cyclohexyl-acetic acid and 1.40 g of (L)-proline benzyl ester hydrochloride using the procedure described for example 91b gave 1.17 g (50%) of the title compound as a colorless oil. (+)-APCI-MS: 403 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06444672B1 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-820d20988b2d4249a5f8ecd94a10f8d7 |
| Source note | uspto-grants-2002_09 |