Hydrochloric Acid → 11-Mercaptoundecanoic Acid

Participants

Reaction Steps

11-Bromoundecanoic acid (20.0 g, 0.075 mol) and thiourea (6.3 g, 1.1 equiv.) were refluxed in ethanol (250 mL) overnight. Sodium hydroxide (6.3 g) in water (20 mL) was added and the mixture was further refluxed for 2 hr. The solution was cooled and acidified with 1N HCl. Ethanol was evaporated under reduced pressure and the aqueous residue was extracted With CH2Cl2. The combined organic extracts were dried (MgSO4) and evaporated to give white powder. Yield: 15.0 g (91%)

Provenance & Evidence