Sulfuric Acid → HCID 20523213, compound

HRID 127917Notes

Reaction equation

HRID 127917 reaction equation
[C:1]([N:4]1[CH2:13][CH2:12][C:11]2[C:6](=[CH:7][C:8]([Cl:14])=[CH:9][CH:10]=2)[CH2:5]1)(=[O:3])[CH3:2].S(=O)(=O)(O)O.[N+:20]([O-])([O-:22])=[O:21].[K+]>>[C:1]([N:4]1[CH2:13][CH2:12][C:11]2[C:6](=[CH:7][C:8]([Cl:14])=[C:9]([N+:20]([O-:22])=[O:21])[CH:10]=2)[CH2:5]1)(=[O:3])[CH3:2]

Participants

4

Reactant 3

HCID 1118Sulfuric Acid2×HCID 24434Potassium NitrateHCID 12838039HCID 12838039, compound

Product 1

HCID 20523213HCID 20523213, compound

Procedure

A solution of 20.9 g. (0.1 mole) of 2-acetyl-7-chloro-1,2,3,4-tetrahydroisoquinoline in 100 ml. of concentrated sulfuric acid is treated with 10 g. (0.1 mole) of potassium nitrate dissolved in 150 ml. of concentrated sulfuric acid. The mixture is stirred for one hour, quenched on ice, made alkaline with ammonium hydroxide and filtered to yield 2-acetyl-7-chloro-6-nitro-1,2,3,4-tetrahydroisoquinoline.

Workup

  1. customquenched on ice
  2. filtrationfiltered

Sources & evidence

ORD record
ord-d9986cae165245eea59c4f1fc477a071
Source dataset
uspto-grants-1981_03
Patent number
US04258049

Reaction notes

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