Dichloromethane → HCID 59035894, compound

Participants

Reaction Steps

A solution of (2R,3R,4S,5S)-4-(benzoyloxy)-5-[(ethylamino)carbonyl]-2-{2-{[(isobutylsulfonyl)amino]methyl}-6-[(4-methoxybenzyl)amino]-9H-purin-9-yl}tetrahydro-3-furanyl benzoate (Preparation 22) (40 mg, 0.05 mmol) in methanol (2 ml) was treated with potassium carbonate (28 mg, 0.20 mmol). The mixture was stirred at room temperature for 20 minutes after which time a precipitate had formed. Dichloromethane (10 ml) was added to the mixture to dissolve the precipitate. The mixture was then filtered and the filtrate was evaporated under reduced pressure. The residue was purified by column chromatography on silica gel eluting with dichloromethane:methanol (95:5 by volume) to afford the title compound as a white solid (21 mg).

Provenance & Evidence