Potassium Hydroxide → HCID 15571589, compound

HRID 127926Notes

Reaction equation

HRID 127926 reaction equation
Cl.[NH2:2][C:3]1[N:8]=[C:7]([NH2:9])[C:6]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[C:13]([OH:19])[CH:12]=2)=[CH:5][N:4]=1.Br[CH2:21][CH2:22][NH:23][S:24](=[O:36])([C:26]1[CH:31]=[CH:30][C:29]([NH:32][C:33](=[O:35])[CH3:34])=[CH:28][CH:27]=1)=[O:25].[OH-].[K+]>CO>[NH2:2][C:3]1[N:8]=[C:7]([NH2:9])[C:6]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[C:13]([O:19][CH2:21][CH2:22][NH:23][S:24](=[O:36])([C:26]3[CH:27]=[CH:28][C:29]([NH:32][C:33](=[O:35])[CH3:34])=[CH:30][CH:31]=3)=[O:25])[CH:12]=2)=[CH:5][N:4]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 4469766HCID 4469766, compoundHCID 15571588HCID 15571588, compound

Product 1

HCID 15571589HCID 15571589, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 1.41 g (0.005 mole) of 2,4-diamino-5-(3'-hydroxy-4'-methoxybenzyl)pyrimidine hydrochloride, 2.0 g (0.00625 mole) of N1 -(2-bromoethyl)-N4 -acetylsulfanilamide, 25 ml of methanol, and 6.0 ml of an aqueous solution containing 0.013 mole of potassium hydroxide is heated at reflux for 1.5 hr.

Workup

  1. temperatureis heated
  2. temperatureat reflux for 1.5 hr

Sources & evidence

ORD record
ord-2079959d162443efae16c592e6961ca2
Source dataset
uspto-grants-1981_03
Patent number
US04258045

Reaction notes

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