Phosphorus oxychloride → HCID 11403413, compound

Participants

Reaction Steps

6-Methyl-3-nitro-4-(1-propylbutylamino)pyridone (3.7 g, 13.84 mmol), was treated with POCl3 (14 mL) at 25° C. for 20 h. Then it was poured into ice/water (200 mL) and extracted with EtOAc (300 mL). The EtOAc was washed with water, brine, dried (MgSO4) and stripped in vacuo. The residue was chromatographed on silica gel (20% EtOAc/hexanes eluting solvent) to give the product (3.3 g).

Provenance & Evidence