Oxalate → HCID 9844424, compound

HRID 1279272Notes

Reaction equation

HRID 1279272 reaction equation
C([O-])(=O)C([O-])=O.[Cl:7][C:8]1[CH:9]=[C:10]([C:15]([N:17]2[CH2:22][CH2:21][C:20]([F:33])([CH2:23][NH:24][CH2:25][CH2:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=3)[CH2:19][CH2:18]2)=[O:16])[CH:11]=[CH:12][C:13]=1F.[Cl:34]C1C=C(C=CC=1Cl)C(N1CCC(F)(C=O)CC1)=O>>[Cl:7][C:8]1[CH:9]=[C:10]([C:15]([N:17]2[CH2:22][CH2:21][C:20]([F:33])([CH2:23][NH:24][CH2:25][CH2:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=3)[CH2:19][CH2:18]2)=[O:16])[CH:11]=[CH:12][C:13]=1[Cl:34]

Participants

4

Reactant 3

HCID 71081OxalateHCID 9800747HCID 9800747, compoundHCID 18427829HCID 18427829, compound

Product 1

HCID 9844424HCID 9844424, compound

Procedure

This compound is obtained in the form of the oxalate according to the same procedure as that used to prepare (3-chloro-4-fluorophenyl){4-fluoro-4-[(2-pyrid-2-ylethylamino)methyl]-1-piperidyl}methanone, but replacing the 1-(3-chloro-4-fluorobenzoyl)-4-fluoropiperidine-4-carbaldehyde with 1-(3,4-dichlorobenzoyl)-4-fluoropiperidine-4-carbaldehyde.

Sources & evidence

ORD record
ord-58e2c6de7a80401ca417bb27d10a6282
Source dataset
uspto-grants-2002_09
Patent number
US06448268B1

Reaction notes

Loading…