Hydrochloric Acid → 3H-Spiro[2-benzothiophene-1,4'-piperidine]--hydrogen chloride (1/1)

Participants

Reaction Steps

150 mg (0.49 mmole) of 1′-t-butoxycarbonylspiro[benzo[c]thiophene-1(3H),4′-piperidine] [prepared as described in step (b) above] were dissolved in 3 ml of anhydrous methylene chloride, and 1 ml of a 4 N solution of hydrogen chloride in dioxane was added. The mixture was then stirred at room temperature for 1 hour. At the end of this time, the crystals which deposited were collected by filtration, to give 108 mg (yield 91%) of the title compound as white crystals.

Provenance & Evidence