HCID 14005903, compound → HCID 86737614, compound

HRID 127935Notes

Reaction equation

HRID 127935 reaction equation
Cl.[NH2:2][C:3]1[N:8]=[C:7]([NH2:9])[C:6]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[C:13]([OH:19])[CH:12]=2)=[CH:5][N:4]=1.[C:20]([NH:23][C:24]1[CH:29]=[CH:28][C:27]([S:30]([CH2:33][CH2:34][CH2:35]Cl)(=[O:32])=[O:31])=[CH:26][CH:25]=1)(=[O:22])[CH3:21]>>[NH2:2][C:3]1[N:8]=[C:7]([NH2:9])[C:6]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[C:13]([O:19][CH2:35][CH2:34][CH2:33][S:30]([C:27]3[CH:28]=[CH:29][C:24]([NH:23][C:20](=[O:22])[CH3:21])=[CH:25][CH:26]=3)(=[O:31])=[O:32])[CH:12]=2)=[CH:5][N:4]=1

Participants

3

Reactant 2

HCID 14005903HCID 14005903, compoundHCID 15571588HCID 15571588, compound

Product 1

HCID 86737614HCID 86737614, compoundYield 80%

Procedure

Following substantially the procedure of Example 1, Step B, 2,4-diamino-5-(3'-hydroxy-4'-methoxybenzyl)pyrimidine hydrochloride is treated with 3-(p-acetamidophenylsulfonyl)propyl chloride to afford 2,4-diamino-5-{3'-[3"-(p-acetamidophenylsulfonyl)propoxy]-4-methoxybenzyl}pyrimidine in 80% yield.

Sources & evidence

ORD record
ord-a73ec2b2e41244608fc3a5c0f65b9b85
Source dataset
uspto-grants-1981_03
Patent number
US04258045

Reaction notes

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