Dicyclohexylcarbodiimide → 1-Methyl-4-piperidyl (5-p-chlorophenyl-1-phenylpyrazol-4-yl)-acetate

Participants

Reaction Steps

A solution of 2.27 g of dicyclohexylcarbodiimide in 10 ml of dry THF is added slowly, at 5°-10°, to a solution of 3.13 g of (5-p-chlorophenyl-1-phenyl-pyrazol-4-yl)-acetic acid in 25 ml of dry THF. The mixture is stirred for 15 minutes at 5°-10°, a solution of 1.23 g of 4-hydroxy-1-methylpiperidine in 10 ml of dry THF is then added at 5°-10°, the resulting mixture is stirred for 3 hours at 20° and subjected to the customary working up, and 1-methyl-4-piperidyl (5-p-chlorophenyl-1-phenylpyrazol-4-yl)-acetate is obtained; m.p. 90°-93°. Hydrochloride, m.p. 234°-236°.

Provenance & Evidence