HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → 3-(Benzyloxy)-2-(1-hydroxypropyl)-6-methyl-4H-pyran-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | 3-Hydroxy-2-(1-hydroxypropyl)-6-methyl-4H-pyran-4-one | HCID 10655077 | — |
| Reactant | 2-hydroxymethyl-3-benzyloxy-6-methyl-pyran-4(1H)-one | HCID 11139409 | — |
| Product | 3-(Benzyloxy)-2-(1-hydroxypropyl)-6-methyl-4H-pyran-4-one | HCID 18678826 | — |
Reaction Steps
The title compound was prepared by the method outlined for 2-hydroxymethyl-3-benzyloxy-6-methyl-pyran-4(1H)-one, using 7.36 g (40 mmol, 1 eq.) of 2-(1-hydroxypropyl)-3-hydroxy-6-methyl-pyran-4(1H)-one and 7.5 g benzyl bromide (44 mmol, 1.1 eq.) to yield the pure product 8.9 g (81.2%) after recrystallisation from CH2Cl2/Pet. ether 40/60, as a white crystalline solid. m.p. 88-89° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06448273B1 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-e075886c1d43470180d253301f1c7daf |
| Source note | uspto-grants-2002_09 |