HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → 2-(Hydroxymethyl)-3-(phenylmethoxy)-4H-pyran-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | 3-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one | HCID 9869622 | — |
| Reactant | 2-hydroxymethyl-3-benzyloxy-6-methyl-pyran-4(1H)-one | HCID 11139409 | — |
| Product | 2-(Hydroxymethyl)-3-(phenylmethoxy)-4H-pyran-4-one | HCID 21792545 | — |
Reaction Steps
The title compound was prepared by the method outlined for 2-hydroxymethyl-3-benzyloxy-6-methyl-pyran-4(1H)-one, using 7.1 g (50 mmol, 1 eq.) of 2-hydroxymethyl-3-hydroxy-pyran-4(1H)-one and 9.5 g benzyl bromide (55 mmol 1.1 eq.) to yield the crude product as an organic oil. Further purification by column chromatography on silica gel (eluant: 10% CH3OH/90% CHCl3) furnished the pure product (9.4 g, 81%) as a bright yellow oil. (Looker and Clifton (1986).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06448273B1 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-c5411fcb1f6449b9840dc8e9cd8ae1f1 |
| Source note | uspto-grants-2002_09 |