Ethylamine → 1-Ethyl-2-methoxymethyl-3-benzyloxy-6-methyl-pyridin-4(1H)-one hydrochloride

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Reaction Steps

The title compound was prepared by the method outlined for 1,6-dimethyl-2-methoxymethyl-3-benzyloxy-pyridin-4(1H)-one hydrochloride, using 6.5 g (25 mmol, 1 eq.) of 2-(1-methoxymethyl)-3-benzyloxy-6-methyl-pyran-4(1H)-one and 4.82 g (75 mmol, 3 eq.) of 70% aqueous ethylamine to yield the pure product 3.7 g (45.7%/) after recrystallisation from methanol/diethyl ether, as a white crystalline solid m.p. 114-116° C.

Provenance & Evidence