HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-Ethyl-2-hydroxymethyl-3-hydroxy-pyridin-4(1H)-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-Ethyl-2-methoxymethyl-3-benzyloxy-pyridin-4(1H)-one | HCID 18678807 | — |
| Reactant | Diethyl ether methanol | HCID 21864698 | — |
| Product | 1-Ethyl-2-hydroxymethyl-3-hydroxy-pyridin-4(1H)-one hydrochloride | HCID 69956498 | 73% |
Reaction Steps
2.0 g (7.33 mmol) 1-ethyl-2-methoxymethyl-3-benzyloxy-pyridin-4(1H)-one was dissolved in 50 ml of 4N hydrochloric acid and refluxed for 6 hours. Concentration to dryness in vacuo afforded the crude product. Recrystalissaion from methanol/diethyl ether gave the pure title compound (1.1 g, 73%) as a white crystalline solid. m.p. 168-169° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06448273B1 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-f4b1362737c449689c0428fe7acb1faf |
| Source note | uspto-grants-2002_09 |