Acetic Anhydride → HCID 54500097, compound

HRID 127942Notes

Reaction equation

HRID 127942 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[N:11]=[CH:10][C:9]=2[CH2:19][CH:20]2[NH:24][CH2:23][CH2:22][S:21]2)=[CH:4][CH:3]=1.[C:25](OC(=O)C)(=[O:27])[CH3:26]>N1C=CC=CC=1>[C:25]([N:24]1[CH2:23][CH2:22][S:21][CH:20]1[CH2:19][C:9]1[CH:10]=[N:11][N:12]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:8]=1[C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1)(=[O:27])[CH3:26]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 23470866HCID 23470866, compound

Product 1

HCID 54500097HCID 54500097, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of 3.56 g of 5-p-chlorophenyl-1-phenyl-4-(thiazolidin-2-yl-methyl)-pyrazole and 55 ml of acetic anhydride is boiled for 3 hours. 55 ml of pyridine is then added and the mixture is heated for a further 5 hours at 50° and subjected to the customary working up. 4-(3-Acetylthiazolidin-2-yl-methyl)-5-p-chlorophenyl-1-phenylpyrazole is obtained; m.p. 121°-122°.

Workup

  1. temperaturethe mixture is heated for a further 5 hours at 50°

Sources & evidence

ORD record
ord-bb2c6f4ba1b3422c8b7dd9a2610d8fdb
Source dataset
uspto-grants-1981_03
Patent number
US04258047

Reaction notes

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