Sodium Hydroxide → HCID 178514392, compound

HRID 1279479Notes

Reaction equation

HRID 1279479 reaction equation
[NH2:1][N:2]=[CH:3][NH:4][C:5]1[CH:29]=[CH:28][C:8]([C:9]([NH:11][C:12]2[CH:13]=[CH:14][C:15]3[O:20][CH:19]([CH2:21][C:22]([O:24]CC)=[O:23])[CH2:18][CH2:17][C:16]=3[CH:27]=2)=[O:10])=[CH:7][CH:6]=1.[OH-].[Na+]>C(O)C>[NH2:1][N:2]=[CH:3][NH:4][C:5]1[CH:29]=[CH:28][C:8]([C:9]([NH:11][C:12]2[CH:13]=[CH:14][C:15]3[O:20][CH:19]([CH2:21][C:22]([OH:24])=[O:23])[CH2:18][CH2:17][C:16]=3[CH:27]=2)=[O:10])=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178470592HCID 178470592, compound

Product 1

HCID 178514392HCID 178514392, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.08 g (0.2 mmol) of the ester from Example 64 were dissolved in 30 ml ethanol followed by addition of 0.4 ml aqueous 2 N sodium hydroxide solution. The mixture was stirred at room temperature for two days, and the mixture was concentrated to dryness under reduced pressure. The residue was dissolved in water, and the solution was neutralized with acetic acid, while the title acid precipitated. It was filtered with suction, washed with water, and dried in vacuo.

Workup

  1. concentrationthe mixture was concentrated to dryness under reduced pressure
  2. dissolutionThe residue was dissolved in water
  3. filtrationIt was filtered with suction
  4. washwashed with water
  5. customdried in vacuo

Sources & evidence

ORD record
ord-8249c14b66e64b45babe13cb9cc7d161
Source dataset
uspto-grants-2002_09
Patent number
US06448269B1

Reaction notes

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