HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-amino-6-methyl-N-(p-tolyl)benzamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-(4-Methylphenyl)-2-{[(1,1-dimethylethoxy)carbonyl]amino]-6-methylbenzamide | HCID 22245130 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-amino-6-methyl-N-(p-tolyl)benzamide hydrochloride | HCID 131723479 | — |
Reaction Conditions
| Temperature | 180 °C |
|---|
Reaction Steps
A stirred solution of N-(4-methylphenyl)-2-([(1,1-dimethylethoxy)carbonyl]amino]-6-methyl-benzamide (1.67 g, 4.90 mmol) in methanol (4 mL) under an argon atmosphere, is treated with a saturated solution of hydrogen chloride in dioxane (30 mL) and stirred at 180° C. for 210 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06448277B2 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-c1b6dcb4a2f94a798d11964d18441744 |
| Source note | uspto-grants-2002_09 |