HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2-methyl-6-nitrobenzoate → Benzoic acid, 2-amino-6-methyl-, methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2-methyl-6-nitrobenzoate | HCID 596057 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Benzoic acid, 2-amino-6-methyl-, methyl ester | HCID 583916 | — |
Reaction Steps
2-Methyl-6-nitrobenzoic acid is reacted with trimethylsilyldiazomethane to yield methyl 2-methyl-6-nitrobenzoate with m.p. 44-45° (Chem. Pharm. Bull., Vol. 29, 1475 (1981)). Methyl 2-methyl-6-nitrobenzoate is hydrogenated in methanol in the presence of palladium, 10% on carbon powder, at room temperature and atmospheric pressure to give methyl 2-methyl-6-aminobenzoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06448277B2 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-b3df42074a4c4b4cadd3da1e3506e480 |
| Source note | uspto-grants-2002_09 |