Sodium Hydroxide → HCID 15859177, compound

Participants

Reaction Steps

180 mg of methyl 5-(3,4,5-trimethoxybenzyloxy)-6-methoxy-1H-indole-2-carboxylate are dissolved in 15 ml of acetone and 3 ml of methanol. 15 ml of 1N sodium hydroxide are added and the mixture is left to react for 2 hours at 30° C. The solvents are evaporated off under vacuum and the residual aqueous phase is acidified to pH=2 with concentrated hydrochloric acid. A solid is obtained, which is purified by taking it up in ethyl acetate at room a temperature.

Provenance & Evidence