HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-Butylamine → 3-(Tert-butylamino)-1,1,1-trichloropropan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-Butylamine | HCID 6385 | — |
| Reactant | 2-(Trichloromethyl)oxirane | HCID 18321 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(Tert-butylamino)-1,1,1-trichloropropan-2-ol | HCID 23471020 | — |
Reaction Steps
The preparation of 2-(trichloromethyl)oxirane is reported by H. Gilman and R. K. Abbott, Jr., J. Org. Chem. 8, 224 (1943). 2-(Trichloromethyl)oxirane can be reacted with 1,1-dimethylethylamine at about -30° to +50° C. in a solvent such as methanol to produce 3-(1,1-dimethylethylamino)-1,1,1-trichloro-2-propanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04258060 |
| Source dataset | uspto-grants-1981_03 |
| ORD ID | ord-8cc396f842784a20afa911fa3eaabb29 |
| Source note | uspto-grants-1981_03 |