Tert-Butylamine → 3-(Tert-butylamino)-1,1,1-trichloropropan-2-ol

Participants

Reaction Steps

To 200 grams of stirred methanol were added 48.4 grams of 2-(trichloromethyl)oxirane and 21.9 grams of 1,1-dimethylethylamine at equimolar rates, dropwise, at 20° C. during 30 minutes. After stirring 16 hours at ambient temperature, the solvent was removed under reduced pressure of 100 mm. Hg and the white residue recrystallized from 300 grams of hexane to yield 50.7 grams of 3-(1,1-dimethylethylamino)-1,1,1-trichloro-2-propanol melting 100.5°-102° C.

Provenance & Evidence