Isopropanol → 1-Isopropyl-1-phenyl-2-(3-sulfamoyl-4-chlorobenzoyl)-hydrazine

Participants

Reaction Steps

Neutralization of the hydrazine hydrochloride of Example 2 was effected by stirring with 19.6 g (0.21 mol) sodium bicarbonate in 100 ml isopropanol. When gas evolution ceased (1 1/2hours) the system was cooled in an ice-water bath, and 25 g (0.1 mol) 3-sulfamoyl-4-chlorobenzoyl chloride was added in several portions. Throughout this addition the temperature was maintained between 5° and 20° C. After the addition the reaction mixture was stirred at room temperature overnight. The reaction mixture was then cooled to 0°-5° C., diluted with 80 ml water, and stirred for 2 more hours.

Provenance & Evidence