HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → 6-Methyl-4-(trifluoromethyl)pyridin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 2-Chloro-6-methyl-4-(trifluoromethyl)pyridine | HCID 2736626 | — |
| Product | 6-Methyl-4-(trifluoromethyl)pyridin-2-amine | HCID 18428521 | — |
Reaction Steps
2-chloro-6-methyl-4-(trifluoromethyl)pyridine (5.0 g) and conc ammonium hydroxide (150 mL) were heated at 180° C. in a steel reaction vessel with mechanical stirring overnight. The contents were allowed to cool and partitioned between CH2Cl2 and water. The CH2Cl2 layer was dried (MgSO4) and concentrated in vacuo leaving 2-amino-6-methyl-4-(trifluoromethyl)pyridine as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06448286B1 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-5df6dbc4e3474393a1853767ab7c75d9 |
| Source note | uspto-grants-2002_09 |