Hydrochloric Acid → HCID 12017646, compound

Participants

Reaction Steps

To a solution of 5-chloroanthranilic acid methyl ester (400 mg;. prepared in Reference Example 1.) and pyridine (0.87 ml) in methylene chloride, benzenesulfonylchloride (0.33 ml) was added at 0° C. The solution was stirred overnight at room temperature. The reaction mixture was poured into diluted HCl and extracted with ethyl acetate. The organic layer was washed, dried over and concentrated under reduced pressure. The residue was purified on silica gel column chromatography (hexane-AcOEt) to give the title compound (664 mg) having the following physical data.

Provenance & Evidence