Sodium Azide → HCID 22672055, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 4-(2-mesyloxymethyl-5-chlorophenoxymethyl)benzoate (628 mg; prepared in Reference Example 48.) in DMF (5.0 ml), sodium azide (530 mg) was added in a stream of argon. The mixture was stirred for 40 minutes at 60° C. The reaction mixture was diluted with ethyl acetate. The impurity was filtered with celite. The filtrate was washed, dried over and concentrated under the reduced pressure. The residue was purified on silica gel column chromatography (hexane:AcOEt =10:1) to give the title compound (404 mg) having the following physical data.

Provenance & Evidence